PIP3 activates AKT signaling PathwayStep5235 PathwayStep5233 PathwayStep5234 PathwayStep5231 PathwayStep5232 TRKA phosphorylates IRS Active IRS recruits PI3K to the plasma membrane and activates it PI3K produces PIP3 and other phosphatidyl inositides PIP3 binds to RhoA and activates it Active TRKA binds IRS1/2 PI3K/AKT activation Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 GENE ONTOLOGYGO:0048015 PI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell death and survival. In addition, it may also use metabolic pathways to regulate cell survival.The PI3K/AKT pathway also affects axon diameter and branching (Marcus et al, 2002) and regulates small G proteins like RhoA (Vanhaesebroeck, B and Waterman, MD, 1999), which control the behaviour of the F-actin cytoskeleton. Moreover, through its connection with the TOR pathway, it promotes translation of a subset of mRNAs. Pubmed10579926 Pubmed12123609 Reactome Database ID Release 43198203 Reactome, http://www.reactome.org ReactomeREACT_12464 Reviewed: Greene, LA, 2007-11-08 15:39:37 PathwayStep3897