RAF/MAP kinase cascade PathwayStep5213 PathwayStep5214 PathwayStep5216 PathwayStep5215 PathwayStep5218 PathwayStep5217 FRS2 binds to active TrkA receptor p-FRS2 binds CRKL FRS2 is phosphorylated by active TrkA receptor (Frs2)C3G stimulates nucleotide exchange on Rap1 Phospho-Frs2:CrkL engages C3G (Frs2)Rap1-GTP binds to and activates B-Raf Frs2-mediated activation Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2006-10-10 09:20:18 Pubmed9069267 Reactome Database ID Release 43170968 Reactome, http://www.reactome.org ReactomeREACT_12076 Reviewed: Greene, LA, 2007-11-08 15:39:37 The adaptor protein Frs2 (Fibroblast growth factor receptor substrate 2) can mediate the prolonged activation of the MAPK (ERK) cascade. PathwayStep3857