RAF/MAP kinase cascade PathwayStep5222 PathwayStep5223 PathwayStep5224 PathwayStep5220 PathwayStep5221 ARMS:Crk complex binds to active TrkA receptor ARMS is phosphorylated by active TrkA receptor Crk's SH3 domain engages C3G (ARMS)Rap1-GTP binds and activates B-Raf C3G stimulates nucleotide exchange on Rap1 ARMS-mediated activation ARMS (Ankyrin-Rich Membrane Spanning/Kidins 220) is a 220kD tetraspanning adaptor protein which becomes rapidly tyrosine phosphorylated by active Trk receptors. ARMS is another adaptor protein which is involved in the activation of Rap1 and the subsequent prolonged activation of the MAPK cascade. Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2006-10-10 09:20:18 Pubmed9069267 Reactome Database ID Release 43170984 Reactome, http://www.reactome.org ReactomeREACT_12002 Reviewed: Greene, LA, 2007-11-08 15:39:37 PathwayStep3857