DAG and IP3 signaling PathwayStep5229 PathwayStep5228 Binding of PLCG1 to active TrkA receptor Active PLCG1 dissociates from TrkA receptor PLC-gamma1 signalling Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07 Edited: Jassal, B, 2006-10-10 09:20:18 GENE ONTOLOGYGO:0007202 Pubmed10579907 Pubmed12676795 Reactome Database ID Release 43167021 Reactome, http://www.reactome.org ReactomeREACT_12079 Reviewed: Greene, LA, 2007-11-08 15:39:37 The activation of phosphlipase C-gamma (PLC-gamma) and subsequent mobilization of calcium from intracellular stores are essential for neurotrophin secretion. PLC-gamma is activated through the phosphorylation by TrkA receptor kinase and this form hydrolyses PIP2 to generate inositol tris-phosphate (IP3) and diacylglycerol (DAG). IP3 promotes the release of Ca2+ from internal stores and this results in activation of enzymes such as protein kinase C and Ca2+ calmodulin-regulated protein kinases. PathwayStep3841