Slit2:Glypican-1 Glypican-1:HSPG Glypican-1 binds Slit2 Authored: Garapati, P V, 2008-09-05 06:02:05 Edited: Garapati, P V, 2008-09-05 06:02:05 Pubmed11375980 Pubmed15063764 Reactome Database ID Release 43428518 Reactome, http://www.reactome.org ReactomeREACT_19262 Reviewed: Kidd, T, 2009-08-18 Slit 2 and both its natural cleavage products bind glypican 1, a glycosyl phosphatidyl inositol (GPI) anchored heparan sulfate proteoglycan (HSPG) through its C terminus. Glypican 1 HSPG is important for high affinity binding of Slit to its receptor and for the repulsive activity of Slit. Slit-Robo signaling strictly requires binding to heparan sulfate. HSPGs may also modulate the extracellular distribution or stability of Slit proteins.