Netrin:DCC:PITP pPLCgamma:PIP2 Phosphorylation of PLCgamma by Netrin-1 Authored: Garapati, P V, 2010-04-13 Edited: Garapati, P V, 2010-04-13 Netrin-1-DCC mediated signaling rapidly phosphorylates PLCgamma. Netrin-1 mediated PLC activation depends on recruitment of PITPalpha to DCC. Stimulation of PLC signaling and hydrolysis of PIP2 by netrin-1 in neurons is time-dependent, with a maximal activity observed within 15 min of netrin-1 stimulation. Pubmed16321979 Reactome Database ID Release 43593690 Reactome, http://www.reactome.org ReactomeREACT_22216 Reviewed: Cooper, HM, 2010-02-16