BoNT BoNT with conformational change in Heavy chain N-terminal Conformational change in BoNT induced by pH Authored: Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11 Edited: Gopinathrao, G, 2006-06-15 22:12:29 Pubmed10212474 Pubmed10518945 Pubmed2424493 Pubmed2446925 Reactome Database ID Release 43168788 Reactome, http://www.reactome.org ReactomeREACT_11131 Reviewed: Ichtchenko, K, 2007-08-03 18:17:25 The N-terminal half of the BoNT Heavy Chain undergoes conformational changes effected by endosomal pH resulting in ion channel formation (Blaustein et al., 1987). This process has been demonstrated experimentally for BoNT serotypes A and B, but all serotypes are thought to have this property (Pellizzari et al. 1999).