BoNT BoNT bound to membrane receptor Transcytosis and internalization of BoNT Authored: Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11 Edited: Gopinathrao, G, 2006-06-15 22:12:29 Once BoNT molecules are bound to the host cell surface via their HC domains, they undergo transcytosis which include sorting and endocytosis into an acidic vesicular compartment within the cytosol. As a result of endocytosis, the toxin becomes resistant to neutralization by antisera. Endocytosis is temperature and energy-dependent. In the body, endocytosed BoNT molecules remain associated with the neuromuscular junction which they finally reach by transcytosis. Pubmed10212474 Pubmed12417130 Pubmed4273827 Pubmed92475 Reactome Database ID Release 43181536 Reactome, http://www.reactome.org ReactomeREACT_11086 Reviewed: Ichtchenko, K, 2007-08-03 18:17:25