BoNT Light chain Types A,C and E BoNT Light chain Types B,D,F,G BoNT with Heavy chain N-terminal inserted into endosomal membrane Transportation of BoNT Light chain to cytosol Authored: Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11 Edited: Gopinathrao, G, 2006-06-15 22:12:29 Pubmed10212474 Pubmed1634516 Pubmed7984234 Reactome Database ID Release 43181365 Reactome, http://www.reactome.org ReactomeREACT_11226 Reviewed: Ichtchenko, K, 2007-08-03 18:17:25 The BoNT L chain traverses the H chain channel into the cytosol, refolds, and is released into the cytosol. The complete molecular details of cleavage of the L- H disulfide bond and L chain refolding are not yet known (Pellizzari et al.,1999). The cleavage of host proteins may require the toxins binding to specific recogntion sites as well as cleavage sites (Rossetto et al., 1994).