Fyn:NCAM1:RPTP-alpha NCAM1 complexed with Fyn Spectrin heterodimer Dephosphorylation of NCAM1 bound pFyn Authored: Garapati, P V, 2009-02-24 10:31:15 EC Number: 3.1.3.48 Edited: Garapati, P V, 2009-02-24 10:58:20 Pubmed12743109 Pubmed15623578 Reactome Database ID Release 43391868 Reactome, http://www.reactome.org ReactomeREACT_18389 Reviewed: Maness, PF, Walmod, PS, 2009--0-5- The homophilic NCAM1:NCAM1 interaction redistributes these molecules and leads to the formation of clusters within lipid rafts. Spectrin, an NCAM1 binding cytoskeletal protein, colocalizes with NCAM1 and codistribute to lipid rafts. Spectrin associates with RPTP-alpha, linking it to the cytoplasmic NCAM1 domain and causing its coredistribution to lipid rafts on NCAM1 clustering. The receptor tyrosine phosphatase RPTP-alpha is an activator of all kinases of the Src family, including Fyn kinase.<p>The interaction of RPTP-alpha and the SH2 domain of Fyn induces an interaction of Fyn Tyr531 with the D1 domain of RPTP-alpha. This induces dephosphorylation of Tyr531 and activates Fyn.