Fyn:NCAM1:RPTP-alpha NCAM1 complexed with pFyn-Y420 Autophosphorylation of NCAM1 bound Fyn Authored: Garapati, P V, 2009-02-24 10:31:15 EC Number: 2.7.10 Edited: Garapati, P V, 2009-02-24 10:58:20 Pubmed15623578 Pubmed9079653 Reactome Database ID Release 43391871 Reactome, http://www.reactome.org ReactomeREACT_18343 Reviewed: Maness, PF, Walmod, PS, 2009--0-5- The Tyr420 residue located in the activation loop of Fyn is responsible for its enzymatic activity. Once the Tyr531 in its negative regulatory site is dephosphorylated by RPTPalpha, Fyn undergoes autophosphorylation on Tyr420 for its maximum activity.