FGFR1c homodimer NCAM1 cis-homodimer NCAM1:FGFR-1 NCAM1 binds FGFR-1 Authored: Garapati, P V, 2009-02-24 10:31:15 Edited: Garapati, P V, 2009-02-24 10:58:20 FGFR is one of the heterophilic interactors of NCAM. The FG loop region of the second Fn3 module of NCAM binds to Ig domains 2 and 3 of FGFR. The FGFR binding site to NCAM overlaps with the site of NCAM-ATP interaction, and ATP is capable of disrupting NCAM-FGFR binding and signaling. <br>The interaction of NCAM activates FGFR and NCAM might merely mimic FGF's in FGFR stimulation, but there is a difference in the activation pattern induced by NCAM and FGF-2. NCAM activated FGFR stimulates neurite outgrowth by stimulating PLCgamma and DAG lipase leading to generation of arachidonic acid. Pubmed12791257 Pubmed16045455 Reactome Database ID Release 43419033 Reactome, http://www.reactome.org ReactomeREACT_18337 Reviewed: Maness, PF, Walmod, PS, 2009--0-5-