G-protein alpha (i):GTP:Adenylate cyclase G-protein alpha (i): GTP Adenylate cyclase (Mg2+ cofactor) G alpha (i) inhibits adenylate cyclase Authored: Jupe, S, 2009-02-26 15:48:59 Edited: Jupe, S, 2009-09-09 G-proteins in the Gi class inhibit adenylate cyclase activity, decreasing the production of cAMP from ATP, which has many consequences but classically results in decreased activity of Protein Kinase A (PKA). cAMP also activates the cyclic nucleotide-gated ion channels, a process that is particularly important in olfactory cells. Pubmed8119955 Pubmed8327893 Reactome Database ID Release 43392206 Reactome, http://www.reactome.org ReactomeREACT_19222 Reviewed: Akkerman, JW, 2009-06-03