Phosphorylation of CREB by CaMKII Authored: Mahajan, SS, 2009-10-29 CaMKII is an important regulator of neuronal plasticity. CaMKII shows distinct subcellular localization and acts quickly in a spatio-temporal manner. CaMKII shows fast synaptic localization upon synaptic activity and also nuclear localization, where it phosphorylates CREB at serine 133 to activate transcription of set of genes that results in long lasting structural changes at the synapse. EC Number: 2.7.11.17 Edited: Gillespie, ME, 2009-06-02 00:56:21 Pubmed11013247 Reactome Database ID Release 43443475 Reactome, http://www.reactome.org ReactomeREACT_20576 Reviewed: Tukey, D, 2009-11-17