Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's CRMP's tetramers Sema3A:Nrp-1:PlexinA:Fyn:pCdk5 Phosphorylation of CRMPs by Cdk5 Authored: Garapati, P V, 2009-03-23 09:59:28 Cdk5:p35 complex is associated with Plexin-A through the actived form of Fyn. CRMPs are the downstream substrates for Cdk5. Cdk5 phosphorylates serine 522 of CRMPs. Phosphorylation of CRMPs mediates the Sema3A induced growth cone collapse.<br>Collapsin response mediator proteins (CRMPs) are five homologous cytosolic phosphoproteins (CRMP1–5) involved in neuronal differentiation and axonal guidance. These members oligomerize and exist as tetramers. EC Number: 2.7.11 Edited: Garapati, P V, 2009-03-23 10:00:07 Pubmed12372285 Pubmed14685275 Pubmed17607942 Reactome Database ID Release 43399944 Reactome, http://www.reactome.org ReactomeREACT_19285 Reviewed: Kumanogoh, A, Kikutani, H, 2009-09-01 has a Stoichiometric coefficient of 4