PathwayStep5704 PathwayStep5728 PathwayStep5722 Class C/3 (Metabotropic glutamate/pheromone receptors) GPCR ligand binding Authored: Jassal, B, 2010-02-05 Edited: Jupe, S, 2010-02-10 Pubmed12688373 Pubmed12761335 Pubmed15251227 Reactome Database ID Release 43500792 Reactome, http://www.reactome.org ReactomeREACT_21340 Reviewed: D'Eustachio, P, 2009-12-11 There are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all physiological processes (Frederiksson 2003). GPCRs are receptors for a diverse range of ligands from large proteins to photons (Kristiansen et al. 2004) and have an equal diversity of ligand-binding mechanisms (Gether et al. 2002). Classical GPCR signaling involves signal transduction via heterotrimeric G-proteins, however many G-protein independent mechanisms have been reported. Class A/1 (Rhodopsin-like receptors) Class B/2 (Secretin family receptors)