H3 and H4 receptors binds histamine H1 receptor binds histamine H2 receptor binds histamine PathwayStep5639 PathwayStep5640 PathwayStep5641 Histamine receptors Authored: Jassal, B, 2009-02-11 13:39:02 Edited: Jassal, B, 2009-02-11 13:39:02 Histamine is a biogenic amine involved in local immune responses, regulation of gut function and neurotransmission. It exerts its actions by binding to histamine receptors. There are four receptors in humans, H1-H4 (Hill SJ et al, 1997). Pubmed9311023 Reactome Database ID Release 43390650 Reactome, http://www.reactome.org ReactomeREACT_16903 Reviewed: D'Eustachio, P, 2009-03-02 09:24:35