BoNT bound to membrane receptor Gangliosides:Synaptotagmin BoNT Binding of BoNT toxins to gut epithelial membrane Authored: Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11 Botulinum neurotoxins (BoNTs) bind to polysialogangliosides, including GT1b, GD1b and GQ1b and synaptotagmin polypeptides on the neuronal plasma membrane (Verderio et al., 2006). In the body, this dual binding may have the effect of targeting BoNTs to specific regions of the neuromuscular junction for endocytosis. Different serotypes are known to bind to different receptors: Bont/A to SV2, Bont/B and G to Syt1 and Syt2 with different affinities. Edited: Gopinathrao, G, 2006-06-15 22:12:29 Pubmed10932256 Pubmed12417130 Pubmed14504267 Pubmed17016457 Pubmed9783260 Reactome Database ID Release 43181359 Reactome, http://www.reactome.org ReactomeREACT_11084 Reviewed: Ichtchenko, K, 2007-08-03 18:17:25