S1P-binding receptors bind S1P LPA-binding receptors bind LPA PathwayStep5688 PathwayStep5689 Lysosphingolipid and LPA receptors Authored: Jassal, B, 2009-04-30 13:38:16 Edited: Jassal, B, 2009-04-30 13:38:16 Pubmed11093753 Pubmed11324705 Pubmed9893266 Reactome Database ID Release 43419408 Reactome, http://www.reactome.org ReactomeREACT_18365 Reviewed: D'Eustachio, P, 2009-05-29 07:44:22 The Lysophospholipid receptor (LPLR) group are members of the G protein-coupled receptor family of integral membrane proteins that are important for lipid signaling. In humans there are eight LPL receptors, each encoded by a separate gene (these genes also sometimes referred to as "Edg" or endothelial differentiation gene). The ligands for LPLRs are the lysophospholipid extracellular signaling molecules, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). The primary effects are inhibition of adenylyl cyclase and release of calcium from the endoplasmic reticulum, as well as secondary effects of preventing apoptosis and increasing cell proliferation (Contos JJ et al, 2000; An S et al, 1998; Fukushima N and Chun J, 2001).