GPR120 is a receptor for unsaturated long-chain free fatty acids Receptor FFAR2 binds carboxylates Receptor FFAR3 binds carboxylates Receptor FFAR1 binds free fatty acids PathwayStep5694 PathwayStep5697 PathwayStep5696 PathwayStep5695 Free fatty acid receptors Authored: Jupe, S, 2009-10-19 Edited: Jupe, S, 2010-03-01 Fatty acids are the ligands for a small family of G-protein-coupled receptors, the Free Fatty Acid receptors, and an unrelated receptor GPR120. <br><br>Free fatty acid receptor 1 (FFAR1/GPR40) is activated by both saturated and unsaturated medium to long-chain fatty acids while FFAR2 (GPR43) and FFAR3 (GPR41) are activated by short-chain fatty acids (carboxylates) with six or fewer carbon molecules. A fourth highly homologous receptor GPR42 is believed to be a pseudogene with intact open reading frame, but could be a functional gene in a significant fraction of the human population. <br><br>GPR120 is activated by long chain (C16-22) fatty acids. Pubmed15684720 Pubmed17052194 Pubmed19630535 Reactome Database ID Release 43444209 Reactome, http://www.reactome.org ReactomeREACT_21268 Reviewed: D'Eustachio, P, 2009-12-11