Activation of Ca2+ activated Potassium channels with small conductance Authored: Mahajan, SS, 2011-05-18 Edited: Mahajan, SS, 2011-05-23 Pubmed19074509 Reactome Database ID Release 431296039 Reactome, http://www.reactome.org ReactomeREACT_75830 Reviewed: Jassal, B, 2010-09-23 Small conductance Ca2+ activated potassium channels (SKca) are solely activated by intracellular Ca2+ concentration. SKca channels form functional tetramers. SKca channels control the contractility of uterus, maintian vascular tone, modulate hormone secretion, control cell volume in red blood cells and activation of microglia and lymphocytes. Actiavtion of SKca channels is triggered by increase in the intracellular Ca2+ ion concentration. Activation of Skca channels leads to relatively small K+ ion effluxes.