Phospho(S363,S380,T573)- ribosomal S6 kinase Phospho(S221,S363,S380,T573)- ribosomal S6 kinase Phophorylation by PDK1 Authored: Mahajan, SS, 2009-10-29 Edited: Gillespie, ME, 2009-06-02 00:56:21 PDK1 activates ribosomal S6 kinase (RSK) by phosphorylating S221. The binding site for PDK1 on RSK is available after RSK phosphorylation by MAPK/ERK. PDK1 is present in the activated form at the plasma membrane where the phosphorylation occurs. The activation of RSK occurs in the cytoplasm, plasma membrane and in the nucleus where it finally activates CREB by phosphorylation. Pubmed10480933 Pubmed12393804 Reactome Database ID Release 43442739 Reactome, http://www.reactome.org ReactomeREACT_20640 Reviewed: Tukey, D, 2009-11-17