Ca impermeable AMPA receptors Membrane depolarization upon activation of Ca impermeable AMPA receptors Authored: Mahajan, SS, 2009-09-29 Edited: Gillespie, ME, 2009-06-02 00:56:21 Membrane depolarization occurs due to glutamate dependent activation of Ca-impermeable AMPA receptors, which permit the influx of Na+ ions. The depolarization triggers the removal of Mg2+ from the NMDA receptor pore to facilitate its activation. Therefore activation of AMPA receptors by glutamate precedes activation of NMDA receptors. Pubmed9648857 Reactome Database ID Release 43438037 Reactome, http://www.reactome.org ReactomeREACT_20569 Reviewed: Tukey, D, 2009-11-17