GRIP1/GRIP2 AP2A GRIP1/GRIP2 Ca impermeable AMPA receptors (with phospho GluR2 S880) Ca impermeable AMPA receptors Endocytosis of Ca impermeable AMPA receptors Authored: Mahajan, SS, 2008-01-14 16:01:52 Edited: Mahajan, SS, 2009-05-31 11:49:00 GluR2 containing AMPA receptors are constitutively recycled between the endosome membrane and the plasma membrane. GRIP and PICK compete for the binding to the C tail of GluR2. Once the GluR2 containing AMPA receptors are in the plasmamembrane, phosphorylation of GluR2 at S880 by PKC causes disruption of GRIP interaction, but not PICK interaction which facilitates internalization of GluR2 containing AMPA receptors into endosomes. Pubmed16055064 Reactome Database ID Release 43421007 Reactome, http://www.reactome.org ReactomeREACT_18308 Reviewed: Ziff, EB, 2009-05-15 16:23:37