Passive Transport of Glycerol out of Cell by Aquaporin-7 Passive Transport of Glycerol into Cell by Aquaporin-9 PathwayStep5006 PathwayStep5005 Transport of Glycerol from Adipocytes to the Liver by Aquaporins Authored: May, B, 2009-08-06 Edited: May, B, 2009-08-06 GENE ONTOLOGYGO:0015793 Pubmed16764946 Pubmed19096781 Reactome Database ID Release 43432030 Reactome, http://www.reactome.org ReactomeREACT_23809 Reviewed: Beitz, E, 2010-06-24 Reviewed: Calamita, G, 2010-07-15 Reviewed: Mathai, JC, MacIver, B, 2010-07-31 Triglycerides stored in adipocytes are hydrolyzed to yield fatty acids and glycerol. The glycerol is passively transported out of the adipocyte and into the bloodstream by Aquaporin-7 (AQP7) located in the plasma membrane of adipocytes. Glycerol in the bloodstream is passively transported into liver cells by AQP9 located in the plasma membrane of hepatocytes. Once inside the liver cell the glycerol is a substrate for gluconeogenesis.