FATP1, 4 and 6 can mediate the influx of long chain fatty acids into cells PathwayStep4975 Transport of fatty acids Authored: Jassal, B, 2010-05-26 Edited: Jassal, B, 2010-05-26 GENE ONTOLOGYGO:0015909 Long chain fatty acids (LCFAs) are involved in many cellular functions. They can be used as an important source of energy by skeletal muscle and heart tissues. Also, they are used in the production of hormones which can regulate inflammation, blood pressure, the clotting process, blood lipid levels and the immune response. Fatty acid transporter proteins (FATPs) are a family of proteins which mediate fatty acid uptake into cells when overexpressed. FATPs also possess enzymatic activity, the details of which are captured elsewhere. There are 6 human genes of the SLC27A family which encode for FATP1-6 (Stahl A, 2004; Gimeno RE, 2007). To date, only FATP1, 4 and 6 have demonstrable transporter function. Fatty acids with carbon chain lengths of more than 10 are the most likely substrates for these transporters. Pubmed12856180 Pubmed17495600 Reactome Database ID Release 43804914 Reactome, http://www.reactome.org ReactomeREACT_23892 Reviewed: He, L, 2010-07-07