SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP SLC35B2 and SLC35B3 mediate the antiport of PAPS into the Golgi lumen in exchange for PAP SLC35A3 mediates the antiport of UDP-GlcNAc in exchange for UMP SLC35A2 mediates the antiport of UDP-Gal and UDP-GalNAc in exchange for UMP SLC35A1 mediates the antiport of CMP-sialic acid in exchange for CMP SLC35D2 mediates the antiport of UDP-sugars in exchange for UMP SLC35C1 mediates the transport of UDP-fucose into the Golgi lumen SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen PathwayStep2697 PathwayStep4973 PathwayStep4970 PathwayStep4972 PathwayStep4971 PathwayStep4965 PathwayStep4966 PathwayStep4967 PathwayStep4968 PathwayStep4969 UDP-glucuronate transport from the cytosol to ER lumen Transport of nucleotide sugars Authored: Jassal, B, 2010-05-12 Edited: Jassal, B, 2010-05-12 Nucleotide sugars are used as sugar donors by glycosyltransferases to create the sugar chains for glycoconjugates such as glycoproteins, polysaccharides and glycolipids. Glycosyltransferases reside mainly in the lumen of the Golgi apparatus and endoplasmic reticulum (ER) whereas nucleotide sugars are synthesized in the cytosol. The human solute carrier family SLC35 encode nucleotide sugar transporters (NSTs) which can mediate the antiport of nucleotide sugars in exchange for the corresponding nucleoside monophosphates (eg. UMP for UDP-sugars). Owing to their function, NSTs are primarily located on Golgi and ER membranes (He L et al, 2009; Handford M et al, 2006; Ishida N and Kawakita M, 2004). Pubmed12759756 Pubmed16981043 Pubmed19164095 Reactome Database ID Release 43727802 Reactome, http://www.reactome.org ReactomeREACT_22151 Reviewed: He, L, 2010-05-10