PathwayStep5038 PathwayStep5035 Ion channel transport Authored: Jassal, B, 2010-11-02 Edited: Jassal, B, 2010-11-02 GENE ONTOLOGYGO:0034220 ISBN0-87893-741-2 Ion channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore for the flow of ions. There are different types of ion channels. P-type ATPases undergo conformational changes to translocate ions. Ligand-gated ion channels operate like a gate, opened or closed by a chemical signal. Voltage-gated ion channels are activated by changes in electrical potential difference at the membrane (Purves, 2001; Kuhlbrandt, 2004). Pubmed15071553 Reactome Database ID Release 43983712 Reactome, http://www.reactome.org ReactomeREACT_25300 Reviewed: He, L, 2010-11-15 Ion transport by P-type ATPases Ligand-gated ion channel transport