Acidification of Tf:TfR1 containing endosome Iron separates from the Tf:TfR1 complex Reduction of Fe3+ in the endosome Iron diffuses out of the endosome Recycling of Tf endosome to plasma membrane apo-Transferrin dissociates from the receptor complex Separation of endosome from the plasma membrane Loaded transferrin binds to TfR1 PathwayStep5018 PathwayStep5017 PathwayStep5019 PathwayStep5020 PathwayStep5021 PathwayStep5022 PathwayStep5023 PathwayStep5016 Transferrin endocytosis and recycling Authored: Stephan, R, 2010-07-11 Edited: Jassal, B, 2010-07-30 Endocytosis of iron loaded transferrin/receptor complex leads, after acidification of the endosome, to the separation of iron and its diffusion out of the vesicle. The endosome is not fused with a lysosome but recycles its content back to the cell surface where soon transferrin dissociates from its receptor (Dautry-Varsat, 1986). GENE ONTOLOGYGO:0033572 Pubmed2874839 Reactome Database ID Release 43917977 Reactome, http://www.reactome.org ReactomeREACT_25283 Reviewed: D'Eustachio, P, 2010-11-05