PathwayStep5109 PathwayStep5102 PathwayStep5058 Signal attenuation IRS-related events Insulin receptor signalling cascade Authored: Bevan, AP, 2003-07-31 08:01:55 Autophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the autophosphorylation of the insulin receptor is its internalisation into an endosome, which downregulates its signalling activity. Pubmed11282018 Pubmed9677303 Reactome Database ID Release 4374751 Reactome, http://www.reactome.org ReactomeREACT_1195 SHC-related events