Dissociation of SHC-P from insulin receptor Phosphorylation of SHC Binding of SHC to insulin receptor PathwayStep5052 PathwayStep5051 PathwayStep5053 SHC activation Authored: 2003-07-28 10:05:14 Reactome Database ID Release 4374744 Reactome, http://www.reactome.org ReactomeREACT_1661 SHC interacts via its SH2 domain with the carboxyterminal phosphorylated tyrosines of the insulin receptor. As a result, SHC is tyrosine phosphorylated (Tyr317) by the insulin receptor, later falling away from the receptor. The phosphorylation of tyrosine 317 of SHC allows GRB2 to bind to it via its SH2 domain.