ZIP7 mediates zinc efflux from the endoplasmic reticulum ZIP6 and ZIP14 mediate zinc influx into cells hZIP5 mediates zinc uptake by cells hZIP1-4 mediate zinc uptake by cells ZIP8 mediates zinc influx into cells hZIP10 mediates zinc influx into cells PathwayStep4912 PathwayStep4911 PathwayStep4914 PathwayStep4913 PathwayStep4916 PathwayStep4915 Zinc influx into cells by the SLC39 gene family Authored: Jassal, B, 2009-09-25 Edited: Jassal, B, 2009-09-25 Pubmed12659941 Pubmed12748861 Reactome Database ID Release 43442380 Reactome, http://www.reactome.org ReactomeREACT_20603 Reviewed: He, L, 2009-11-12 The SLC39 gene family encode zinc transporters belonging to the ZIP (Zrt-, Irt-like proteins) family of metal ion transporters. All ZIPs transport metal ions into the cytoplasm of cells, be it across cellular membranes or from intracellular compartments. To date, there are 14 human SLC39 genes that encode the zinc transporters hZIP1-14. There are 9 members which belong to a subfamily of the ZIPs called the LZTs (LIV-1 subfamily of ZIP zinc transporters) (Taylor KM and Nicholson RI, 2003). Of these 14 proteins, four (hZIP9, 11, 12 and 13) have no function determined yet (Eide DJ, 2004).