PathwayStep887 PathwayStep888 PathwayStep878 PathwayStep876 PathwayStep877 PathwayStep874 PathwayStep875 VMAT1/2 can mediate the transport of biogenic amines NAT1 mediates norepinephrine uptake GLYT1/2 mediate glycine uptake PROT mediates L-proline uptake PathwayStep4925 PathwayStep4924 PathwayStep4923 PathwayStep4922 SLC6A14-mediated uptake of basic and neutral amino acids and of beta-alanine SLC6A19-mediated uptake of neutral amino acids SLC6A12 (BGT-1)-mediated uptake of GABA and betaine SLC6A15-mediated amino acid uptake SLC6A18-mediated glycine uptake SLC6A20-mediated uptake of proline SLC6A6-mediated uptake of taurine and beta-alanine PathwayStep3272 PathwayStep3280 PathwayStep3288 PathwayStep3243 GAT1-3 mediate Na+/Cl- dependent GABA transport Uptake of Noradrenaline Reuptake of serotonin from the synapse Reuptake of dopamine from the synaptic cleft into neurons Na+/Cl- dependent neurotransmitter transporters Authored: Jassal, B, 2009-09-29 Edited: Jassal, B, 2009-09-29 Pubmed12719981 Reactome Database ID Release 43442660 Reactome, http://www.reactome.org ReactomeREACT_20506 Reviewed: He, L, 2009-11-12 The SLC6 gene family encodes proteins that mediate neurotransmitter uptake thus terminating a synaptic signal. The proteins mediate transport of GABA (gamma-aminobutyric acid), norepinephrine, dopamine, serotonin, glycine, taurine, L-proline, creatine and betaine. These transporters are mainly present in the CNS and PNS (Chen NH et al, 2004).