PathwayStep4948 PathwayStep4944 Organic cation/anion/zwitterion transport Authored: Jassal, B, 2010-03-17 Edited: Jassal, B, 2010-03-17 Pubmed12883891 Reactome Database ID Release 43549132 Reactome, http://www.reactome.org ReactomeREACT_22345 Reviewed: He, L, 2010-05-10 The SLC22 gene family of solute carriers function as organic cation transporters (OCTs), cation/zwitterion transporters (OCTNs) and organic anion transporters (OATs). The SLC22 family belongs to the major facilitator superfamily and comprises uniporters, symporters and antiporters.Most of this family are polyspecific transporters. Since many of these transporters are expressed in the liver, kidney and intestine, they play an important role in drug absorption and excretion. Substrates include xenobiotics, drugs, and endogenous amine compounds (Koepsell H and Endou H, 2004). Organic cation transport Organic anion transport