Carnitine transporters mediates sodium-dependent uptake of carnitine ORCTL2 mediates the transport of chloroquine and quinidine with efflux of protons OCT3 mediates renal uptake of organic cations OCT4 mediates transport of ergothioneine OCT3 mediates renal clearance of organic cations OCT2 mediates tubular secretion of organic cations in the kidney OCT1 transports organic cations out of hepatic cells OCT2 mediates tubular uptake of organic cations in the kidney OCT1 transports organic cations into hepatic cells PathwayStep4936 PathwayStep4935 PathwayStep4938 PathwayStep4937 PathwayStep4939 PathwayStep4940 PathwayStep4941 PathwayStep4942 PathwayStep4943 Organic cation transport Authored: Jassal, B, 2010-03-17 Edited: Jassal, B, 2010-03-17 Pubmed12883891 Reactome Database ID Release 43549127 Reactome, http://www.reactome.org ReactomeREACT_22357 Reviewed: He, L, 2010-05-10 The organic cation transporters comprise three SLC22 members, OCT1-3. They can transport a wide range of organic cations including weak bases. All transport by OCTs is electrogenic, sodium-independent and bidirectional. Two further organic cation transporters mediate transport of ergothioneine and carnitine (Koepsell H and Endou H, 2004).