M2 mRNA M2 mRNA NS2 mRNA NS2 mRNA Export of Spliced Viral mRNA Authored: Bortz, E, Garcia-Sastre, A, 2007-02-12 19:39:05 In the cases of spliced, polyadenylated mRNA transcribed from M (segment 7) and NS (segment 8) vRNA templates (producing the spliced mRNA for M2 and NS2/NEP, respectively), export may be coupled to aspects of the cellular splicing and export mechanisms (Chen, 2000; Alonso-Caplan et al, 1992; Amorim, 2006). Simultaneously, the export of cellular mRNA appear to be inhibited by the viral NS1 protein, which binds to the cellular cleavage and polyadenylation specificity factor (CPSF), preventing polyadenylation and completion of pre-mRNA processing (Nemerof et al., 1998; Fortes, 1994; Lu, 1994; Li, 2001). Pubmed10920397 Pubmed11421366 Pubmed1531330 Pubmed7958859 Pubmed8313914 Pubmed9651582 Reactome Database ID Release 43192925 Reactome, http://www.reactome.org ReactomeREACT_9528 Reviewed: Squires, B, 2007-02-12 19:39:22