viral mRNA viral mRNA Viral mRNA Export Authored: Bortz, E, Garcia-Sastre, A, 2007-02-12 19:39:05 Pubmed10590131 Pubmed10920397 Pubmed15827195 Pubmed16933365 Pubmed17132145 Reactome Database ID Release 43192627 Reactome, http://www.reactome.org ReactomeREACT_9529 Reviewed: Squires, B, 2007-02-12 19:39:22 The viral polymerase complex produces positive-sense viral mRNA with host-cell derived 5' methyl caps. Capped viral mRNAs are selectively exported from the host cell nucleus through a currently unclear mechanism that may rely on components of the host cell mRNA export machinery (Chen, 2000; Engelhardt, 2006). Polyadenylation of viral mRNA appears be required for influenza mRNA export (Poon, 2000). A coupling of viral mRNA export with cellular pre-mRNA processing complexes, recruited by phosphorylation of host RNA polymerase II C-terminal domain which interacts with the viral polymerase (Engelhardt, 2005), has been proposed as controlling the export of a subset (M1, HA, and NS1, but not NP) of viral mRNA from the nucleus (Amorim, 2007).