Viral Polymerase vRNA (Genomic):NP Complex cRNP Initiated vRNA-cRNA Complex NTP cRNA Extension Authored: Bortz, E, Garcia-Sastre, A, 2007-02-12 19:39:05 EC Number: 2.7.7.48 Pubmed15308750 Pubmed17166911 Pubmed8709268 Reactome Database ID Release 43192624 Reactome, http://www.reactome.org ReactomeREACT_9404 Reviewed: Squires, B, 2007-02-12 19:39:22 Virion vRNP is capable of synthesizing cRNA immediately following entry into the cell nucleus (Vreede, 2006). The PB1 subunit principally catalyzes extension (Nakagawa, 1996). However, cRNA does not accumulate until later in the infection process, possiby requiring NP and the trimeric polymerase for stabilization (Vreede, 2004). The vRNA template is released. has a Stoichiometric coefficient of 3