Initiated vRNA Transcription Complex Elongated vRNA-mRNA Complex NTP Elongation of viral mRNA Authored: Bortz, E, Garcia-Sastre, A, 2007-02-12 19:39:05 Catalyzed by the RNA polymerase activity of the viral PB1 subunit, an mRNA complementary to the bound vRNA is synthesized (Plotch, 1977). PA and PB2 move down the growing mRNA in complex with PB1, with PB2 possibly dissociating from the cap (Braam, 1983). However, the 5’ end of the vRNA may remain bound during elongation as the template is threaded through in a 3’ to 5’ direction until a polyadenylation signal is encountered (Poon, 1998; Zheng, 1999). EC Number: 2.7.7.48 GENE ONTOLOGYGO:0019083 Pubmed10233995 Pubmed6616622 Pubmed833924 Pubmed9733864 Reactome Database ID Release 43168334 Reactome, http://www.reactome.org ReactomeREACT_6210 Reviewed: Squires, B, 2007-02-12 19:39:22