RNP:Karyopherin alpha:Karyopherin beta complex RNP:Karyopherin alpha:Karyopherin beta complex Docking and transport of the RNP:Karyopherin complex through the nuclear pore Authored: Gillespie, ME, 2005-11-14 17:18:07 GENE ONTOLOGYGO:0046796 Pubmed1985200 Reactome Database ID Release 43168337 Reactome, http://www.reactome.org ReactomeREACT_6289 Reviewed: Squires, B, 2006-10-29 16:42:09 These RNPs (10-20nm wide) are too large to passively diffuse into the nucleus and therefore, once released from an incoming particle they must rely on the active import mechanism of the host cell nuclear pore complex (NPC). Once the RNP heterodimeric karyopherin complex docks at the NPC, it is transported into the nucleus.