Vif:APOBEC3G complex Vif APOBEC3G Association of Vif with APOBEC3G Authored: Matthews, L, 2006-05-15 23:53:25 Edited: Matthews, L, 2007-01-30 11:27:41 Pubmed14528301 Pubmed14978281 Pubmed14999100 Pubmed16501124 Reactome Database ID Release 43180602 Reactome, http://www.reactome.org ReactomeREACT_9445 Reviewed: Mulder, L, 2007-01-30 22:57:00 Reviewed: Simon, V, 2007-01-30 23:07:12 The HIV-1 Vif protein associates with the DNA editing enzyme APOBEC3G Marin et al) . The binding site has not yet been mapped but emerging evidence suggest that the N-terminal lregion of Vif is essential for APOBEC3G recognition (Tian et al) . <br>Substitution of a single amino acid in the human APOBEC3G (Asp128Lys) abolishes binding and renders it resistant to HIV-1 Vif (Schrofelbauer et al; Bogerd et al.). <br>