<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/HP?iri=http://purl.obolibrary.org/obo/CL_0000788"?>
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     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:core="http://purl.obolibrary.org/obo/uberon/core#"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:cl="http://purl.obolibrary.org/obo/cl#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:ns4="http://purl.obolibrary.org/obo/"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/cl#cellxgene_subset"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Object Properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/CL_4030044 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/CL_4030044">
        <rdfs:label>has_not_completed</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/CL_4030046 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/CL_4030046">
        <rdfs:label>lacks_plasma_membrane_part</rdfs:label>
    </ObjectProperty>
    


    <!-- http://purl.obolibrary.org/obo/RO_0002104 -->

    <ObjectProperty rdf:about="http://purl.obolibrary.org/obo/RO_0002104">
        <rdfs:label xml:lang="en">has plasma membrane part</rdfs:label>
    </ObjectProperty>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/CL_0000785 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000785">
        <rdfs:label>mature B cell</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CL_0000788 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CL_0000788">
        <rdfs:label>naive B cell</rdfs:label>
        <equivalentClass>
            <Class>
                <intersectionOf rdf:parseType="Collection">
                    <rdf:Description rdf:about="http://purl.obolibrary.org/obo/CL_0000785"/>
                    <Restriction>
                        <onProperty rdf:resource="http://purl.obolibrary.org/obo/CL_4030044"/>
                        <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0002344"/>
                    </Restriction>
                    <Restriction>
                        <onProperty rdf:resource="http://purl.obolibrary.org/obo/CL_4030046"/>
                        <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000001963"/>
                    </Restriction>
                    <Restriction>
                        <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002104"/>
                        <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0071738"/>
                    </Restriction>
                    <Restriction>
                        <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002104"/>
                        <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0071753"/>
                    </Restriction>
                    <Restriction>
                        <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002104"/>
                        <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000001289"/>
                    </Restriction>
                </intersectionOf>
            </Class>
        </equivalentClass>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CL_0000785"/>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/CL_4030044"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0002344"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002104"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000001289"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002104"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0071738"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/RO_0002104"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/GO_0071753"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:subClassOf>
            <Restriction>
                <onProperty rdf:resource="http://purl.obolibrary.org/obo/CL_4030046"/>
                <someValuesFrom rdf:resource="http://purl.obolibrary.org/obo/PR_000001963"/>
            </Restriction>
        </rdfs:subClassOf>
        <rdfs:comment>This cell type is compatible with the HIPC Lyoplate markers for &#39;naive B cell&#39;. Per DSD: Naive B cells are also reportedly CD10-negative, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD25-negative, CD27-negative, CD34-negative, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD80-negative, CD81-positive, CD84-positive, CD86-negative, CD95-negative, CD138-negative, CD150-positive, CD184/CXCR4-positive, CD185/CXCR5-positive, CD196/CCR6-positive, CD200-positive, CD229-positive, CD243-positive, CD289-positive, CD290-positive, CD352-positive, MHCII/HLA-DR-positive, cadherin 9-positive, and sIgH-positive, Transcription factors: Pax5-positive, ETS1-positive, FOXO1A-positive, KLF4-positive, KLF9-positive, MiTF-positive, OBF1-positive, PLZF-positive, and SpiB-positive.</rdfs:comment>
        <oboInOwl:hasExactSynonym>naive B-lymphocyte</oboInOwl:hasExactSynonym>
        <ns4:IAO_0000115>A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery.</ns4:IAO_0000115>
        <oboInOwl:hasExactSynonym>naive B-cell</oboInOwl:hasExactSynonym>
        <oboInOwl:hasExactSynonym>naive B lymphocyte</oboInOwl:hasExactSynonym>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/cl#cellxgene_subset"/>
        <oboInOwl:inSubset rdf:resource="http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas"/>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/GO_0002344 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/GO_0002344">
        <rdfs:label>B cell affinity maturation</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/GO_0071738 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/GO_0071738">
        <rdfs:label>IgD immunoglobulin complex</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/GO_0071753 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/GO_0071753">
        <rdfs:label>IgM immunoglobulin complex</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/PR_000001289 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/PR_000001289">
        <rdfs:label>membrane-spanning 4-domains subfamily A member 1</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/PR_000001963 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/PR_000001963">
        <rdfs:label>CD27 molecule</rdfs:label>
    </Class>
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<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



