capable of double negative thymocyte double negative T regulatory cell A double negative thymocyte that is CD3-positive, CD4-negative, CD8-negative, that that are present in the periphery in very low numbers and predominantly produce INF-gamma, TNF-alpha, and a low amount of TGF-beta, but not IL-2, IL-4, IL-10 or IL-13 upon activation. double-negative alpha-beta regulatory T cell CD4-negative, CD8-negative, alpha-beta regulatory T cells DN Treg negative regulation of immune response