myeloid leukocyte differentiation granulocyte differentiation GO:0030851 granulocyte cell differentiation Reactome:R-HSA-9616222 The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.