negatively regulates cellular component organization negative regulation of cellular process regulation of cellular component organization negative regulation of cellular component organization Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope. negative regulation of cellular component organization and biogenesis down regulation of cell organization down-regulation of cell organization downregulation of cell organization GO:0051129 inhibition of cell organization negative regulation of cell organisation biological regulation