negatively regulates negative regulation of developmental process cartilage development negative regulation of multicellular organismal process regulation of cartilage development negative regulation of cartilage development 2010-02-09T03:41:35Z GO:0061037 Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate. biological regulation