All Mode of inheritance HP:0001453 While there is a close conceptual relationship between allelic requirement and inheritance, they serve different purposes; allelic requirement is necessary for variant annotation pipelines and to determine if a given variant in a specific context is relevant to the phenotype of the patient e.g. a heterozygous variant (in the absence of compound heterozygosity) is relevant for dominant but not for recessive disease; while inheritance is used for describing the mode of inheritance of a phenotype and is particularly applicable in the clinical setting for communicating recurrence risk, to guide family screening, and to guide reproductive advice. HP:0000005 Inheritance HP:0001461 UMLS:C1708511 The pattern in which a particular genetic trait or disorder is passed from one generation to the next. HP:0010985 HP:0001425