Leukocoria UMLS:C0152458 An abnormal white reflection from the pupil rather than the usual black reflection. The word leukocoria literally means white pupil, but leukocoria is not an abnormality of the pupil. Rather, leukocoria can be caused by cataract, retinal detachment, retinopathy of prematurity, retinal malformation, endophthalmitis, retinal vascular abnormality, and intraocular tumor (e.g., retinoblastoma). SNOMEDCT_US:1361009 Leukokoria HP:0000555 White pupillary reflex Abnormal pupil morphology