Buphthalmos Enlarged eyeball Diffusely large eye (with megalocornea) associated with glaucoma. UMLS:C4551507 Buphthalmos refers to a congenital open-angle glaucoma of the eye. The term buphthalmos (from Greek 'bous' or ox and 'ophthalmos' or eye) is descriptive of an enlarged eyeglobe resulting from increased intraocular pressure. The eyeglobe is especially prone to distension in newborns and infants because its collagen filaments are not as rigid as in adults and may easily be stretched. HP:0000557 Developmental glaucoma Abnormally large globe