has part has part characteristic of inheres in has modifier Hyperactive renin-angiotensin system UMLS:C3150267 UMLS:C1846345 An abnormally increased activity of the renin-angiotensin system, causing hypertension by a combination of volume excess and vasoconstrictor mechanisms. If the kidneys sense reduced renal blood flow, as can happen with reduced blood pressure, they secrete renin into the blood, where it reacts with angiotensinogen to produce angiotensin I, which is converted to angiotensin II by angiotensin converting enzyme (ACE). Both angiotensin I and II are vasoconstrictors. Angiotensin II additionally leads to the production of aldosterone by the adrenal cortex, which in turn leads to an increase in blood volume. HP:0000841 Increased plasma renin activity Abnormality of renin-angiotensin system abnormal increased behavioural activity renin-angiotensin system